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1

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

Giustiniano, Mariateresa, Basso, Andrea, Mercalli, Valentina, Massarotti, Alberto, Novellino, Ettore, Tron, Gian Cesare, Zhu, Jieping

Journal:

Chemical Society Reviews

Year:

2017

Language:

english

File:

PDF, 4.11 MB

english, 2017

2

Click chemistry reactions in medicinal chemistry: Applications of the 1,3-dipolar cycloaddition between azides and alkynes

Gian Cesare Tron, Tracey Pirali, Richard A. Billington, Pier Luigi Canonico, Giovanni Sorba, Armando A. Genazzani

Journal:

Medicinal Research Reviews

Year:

2008

Language:

english

File:

PDF, 391 KB

english, 2008

3

Exploiting the Acylating Nature of the Imide-Ugi Intermediate: A Straightforward Synthesis of Tetrahydro-1,4-benzodiazepin-2-ones

Mossetti, Riccardo, Saggiorato, Dèsirèe, Tron, Gian Cesare

Journal:

Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 342 KB

english, 2011

4

Bisnorsesquiterpenoids from Euphorbia resinifera Berg. and an Expeditious Procedure to Obtain Resiniferatoxin from Its Fresh Latex

Ernesto Fattorusso, Virginia Lanzotti, Orazio Taglialatela-Scafati, Gian Cesare Tron, Giovanni Appendino

Journal:

European Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 323 KB

english, 2002

5

Pietro Biginelli: The Man Behind the Reaction

Gian Cesare Tron, Alberto Minassi, Giovanni Appendino

Journal:

European Journal of Organic Chemistry

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

6

Polycyclic diterpenoids from Euphorbia characias

Giovanni Appendino, Emanuela Belloro, Gian Cesare Tron, Jasmin Jakupovic, Mauro Ballero

Journal:

Year:

2000

Language:

english

File:

PDF, 163 KB

english, 2000

7

Synthesis of NO-Donor Bisphosphonates and Their in-Vitro Action on Bone Resorption

Lazzarato, Loretta, Rolando, Barbara, Lolli, Marco L., Tron, Gian Cesare, Fruttero, Roberta, Gasco, Alberto, Deleide, Guido, Guenther, Harald L.

Journal:

Journal of Medicinal Chemistry

Year:

2005

Language:

english

File:

PDF, 134 KB

english, 2005

8

ZINClick: A Database of 16 Million Novel, Patentable, and Readily Synthesizable 1,4-Disubstituted Triazoles

Massarotti, Alberto, Brunco, Angelo, Sorba, Giovanni, Tron, Gian Cesare

Journal:

Journal of Chemical Information and Modeling

Year:

2014

Language:

english

File:

PDF, 3.08 MB

english, 2014

9

Diterpenoids from Euphorbia p ithyusa subsp. c upanii

Appendino, Giovanni, Belloro, Emanuela, Tron, Gian Cesare, Jakupovic, Jasmin, Ballero, Mauro

Journal:

Journal of Natural Products

Year:

1999

Language:

english

File:

PDF, 124 KB

english, 1999

10

An Expeditious Procedure for the Isolation of Ingenol from the Seeds of Euphorbia l athyris

Appendino, Giovanni, Tron, Gian Cesare, Cravotto, Giancarlo, Palmisano, Giovanni, Jakupovic, Jasmin

Journal:

Journal of Natural Products

Year:

1999

Language:

english

File:

PDF, 56 KB

english, 1999

11

Macrocyclic Diterpenoids from Euphorbia s emiperfoliata

Appendino, Giovanni, Jakupovic, Sven, Tron, Gian Cesare, Jakupovic, Jasmin, Milon, Veronique, Ballero, Mauro

Journal:

Journal of Natural Products

Year:

1998

Language:

english

File:

PDF, 179 KB

english, 1998

12

Visible light photocatalysis in the late-stage functionalization of pharmaceutically relevant compounds

Cannalire, Rolando, Pelliccia, Sveva, Sancineto, Luca, Novellino, Ettore, Tron, Gian Cesare, Giustiniano, Mariateresa

Journal:

Chemical Society Reviews

Year:

2021

File:

PDF, 59.75 MB

2021

13

Synthesis of Modified Ingenol Esters

Giovanni Appendino, Gian Cesare Tron, Giancarlo Cravotto, Giovanni Palmisano, Rita Annunziata, Germano Baj, Nicola Surico

Journal:

European Journal of Organic Chemistry

Year:

1999

Language:

english

File:

PDF, 338 KB

english, 1999

14

A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction

Giovanni Battista Giovenzana, Gian Cesare Tron, Stefano Di Paola, Ivan Guglielmo Menegotto, Tracey Pirali

Journal:

Angewandte Chemie

Year:

2006

Language:

english

File:

PDF, 113 KB

english, 2006

15

A Mimicry of Primary Amines by Bis-Secondary Diamines as Components in the Ugi Four-Component Reaction

Giovanni Battista Giovenzana, Gian Cesare Tron, Stefano Di Paola, Ivan Guglielmo Menegotto, Tracey Pirali

Journal:

Angewandte Chemie International Edition

Year:

2006

Language:

english

File:

PDF, 113 KB

english, 2006

16

ChemInform Abstract: Unnatural Natural Products from the Transannular Cyclization of Lathyrane Diterpenes.

Giovanni Appendino, Gian Cesare Tron, Tomas Jarewaang, Olov Sterner

Journal:

Year:

2001

File:

PDF, 28 KB

2001

17

Chemoselective Esterification of Phenolic Acids and Alcohols.

Giovanni Appendino, Alberto Minassi, Nives Daddario, Federica Bianchi, Gian Cesare Tron

Journal:

Year:

2003

File:

PDF, 136 KB

2003

18

Development of a New Class of Potential Antiatherosclerosis Agents: NO-Donor Antioxidants.

Clara Cena, Donatella Boschi, Gian Cesare Tron, Kostantin Chegaev, Loretta Lazzarato, Antonella Di Stilo, Manuela Aragno, Roberta Fruttero, Alberto Gasco

Journal:

Year:

2005

File:

PDF, 15 KB

2005

19

A Three-Component Synthesis of (1,3-Oxazol-2-yl)-1,2-dihydro(iso)quinoline and Its Further Structural Diversifications.

Gian Cesare Tron, Jieping Zhu

Journal:

Year:

2005

File:

PDF, 24 KB

2005

20

ChemInform Abstract: Stereoselective Synthesis of trans-β-Lactams by Palladium-Catalyzed Carbonylation of Vinyl Aziridines.

Francesco Fontana, Gian Cesare Tron, Nekane Barbero, Serena Ferrini, Stephen P. Thomas, Varinder K. Aggarwal

Journal:

Year:

2010

File:

PDF, 169 KB

2010

21

ChemInform Abstract: Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides.

Riccardo Mossetti, Tracey Pirali, Gian Cesare Tron, Jieping Zhu

Journal:

Year:

2010

File:

PDF, 27 KB

2010

22

ChemInform Abstract: A Practical Synthesis of 5-Aroyl-1-aryltetrazoles Using an Ugi-Like 4-Component Reaction Followed by a Biomimetic Transamination.

Mariateresa Giustiniano, Tracey Pirali, Alberto Massarotti, Beatrice Biletta, Ettore Novellino, Pietro Campiglia, Giovanni Sorba, Gian Cesare Tron

Journal:

Year:

2011

File:

PDF, 29 KB

2011

23

ChemInform Abstract: Replacement of the Double Bond of Antitubulin Chalcones with Triazoles and Tetrazoles: Synthesis and Biological Evaluation.

Gian Cesare Tron, et al. et al.

Journal:

Year:

2011

Language:

english

File:

PDF, 35 KB

english, 2011

24

ChemInform Abstract: A Novel α-Isocyanoacetamide-Based Three-Component Reaction for the Synthesis of Dialkyl 2-Acyl-5-aminofuran-3,4-dicarboxylates.

Riccardo Mossetti, Diego Caprioglio, Giampiero Colombano, Gian Cesare Tron, Tracey Pirali

Journal:

Year:

2011

File:

PDF, 28 KB

2011

25

ChemInform Abstract: Imides: Forgotten Players in the Ugi Reaction. One-Pot Multicomponent Synthesis of Quinazolinones.

Riccardo Mossetti, Tracey Pirali, Desiree Saggiorato, Gian Cesare Tron

Journal:

Year:

2011

File:

PDF, 44 KB

2011

26

ChemInform Abstract: Stereospecific Synthesis of syn-α-Oximinoamides by a Three-Component Reaction of Isocyanides, syn-Chlorooximes, and Carboxylic Acids.

Tracey Pirali, Riccardo Mossetti, Simona Galli, Gian Cesare Tron

Journal:

Year:

2011

File:

PDF, 36 KB

2011

27

ChemInform Abstract: Pietro Biginelli: The Man Behind the Reaction.

Gian Cesare Tron, Alberto Minassi, Giovanni Appendino

Journal:

Year:

2012

File:

PDF, 18 KB

2012

28

Synthesis, chiral HPLC resolution and configuration assignment of 1-phenylglyceryl trinitrate stereomers

Konstantin Chegaev, Loretta Lazzarato, Gian Cesare Tron, Domenica Marabello, Antonella Di Stilo, Clara Cena, Roberta Fruttero, Alberto Gasco, Nicolas Vanthuyne, Christian Roussel

Journal:

Year:

2006

Language:

english

File:

PDF, 157 KB

english, 2006

29

Synthesis and Biological Evaluation of Isosteric Analogues of FK866, an Inhibitor of NAD Salvage

Ubaldina Galli, Emanuela Ercolano, Lorenzo Carraro, Cintia R. Blasi Roman, Giovanni Sorba, Pier Luigi Canonico, Armando A. Genazzani, Gian Cesare Tron, Richard A. Billington

Journal:

Year:

2008

Language:

english

File:

PDF, 275 KB

english, 2008

30

Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry

Daniela Imperio, Tracey Pirali, Ubaldina Galli, Francesca Pagliai, Laura Cafici, Pier Luigi Canonico, Giovanni Sorba, Armando A. Genazzani, Gian Cesare Tron

Journal:

Bioorganic & Medicinal Chemistry

Year:

2007

Language:

english

File:

PDF, 278 KB

english, 2007

31

Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Clara Cena, Donatella Boschi, Gian Cesare Tron, Kostantin Chegaev, Loretta Lazzarato, Antonella Di Stilo, Manuela Aragno, Roberta Fruttero, Alberto Gasco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 274 KB

english, 2004

32

Synthesis and biological activity of mustard derivatives of combretastatins

Beatrice Coggiola, Francesca Pagliai, Gianna Allegrone, Armando A. Genazzani, Gian Cesare Tron

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 203 KB

english, 2005

33

Design, synthesis, and biological evaluation of new (2E,6E)-10-(dimethylamino)-3,7-dimethyl-2,6-decadien-1-ol ethers as inhibitors of human and Trypanosoma cruzi oxidosqualene cyclase

Ubaldina Galli, Simonetta Oliaro-Bosso, Silvia Taramino, Serena Venegoni, Emanuele Pastore, Gian Cesare Tron, Gianni Balliano, Franca Viola, Giovanni Sorba

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 152 KB

english, 2007

34

Ingenol esters induce apoptosis in Jurkat cells through an AP-1 and NF-κB independent pathway

Magdalena Blanco-Molina, Gian Cesare Tron, Antonio Macho, Concepción Lucena, Marco A. Calzado, Eduardo Muñoz, Giovanni Appendino

Journal:

Chemistry & Biology

Year:

2001

Language:

english

File:

PDF, 578 KB

english, 2001

35

Synthesis, molecular docking and biological evaluation as HDAC inhibitors of cyclopeptide mimetics by a tandem three-component reaction and intramolecular [3+2] cycloaddition

Tracey Pirali, Valeria Faccio, Riccardo Mossetti, Ambra A. Grolla, Simone Di Micco, Giuseppe Bifulco, Armando A. Genazzani, Gian Cesare Tron

Journal:

Molecular Diversity

Year:

2010

Language:

english

File:

PDF, 458 KB

english, 2010

36

Identification of Novel Antitubulin Agents by Using a Virtual Screening Approach Based on a 7-Point Pharmacophore Model of the Tubulin Colchi-Site

Alberto Massarotti, Sewan Theeramunkong, Ornella Mesenzani, Antonio Caldarelli, Armando A. Genazzani, Gian Cesare Tron

Journal:

Chemical Biology & Drug Design

Year:

2011

Language:

english

File:

PDF, 909 KB

english, 2011

37

NO-Donor Phenols: A New Class of Products Endowed with Antioxidant and Vasodilator Properties

Boschi, Donatella, Tron, Gian Cesare, Lazzarato, Loretta, Chegaev, Konstantin, Cena, Clara, Di Stilo, Antonella, Giorgis, Marta, Bertinaria, Massimo, Fruttero, Roberta, Gasco, Alberto

Journal:

Journal of Medicinal Chemistry

Year:

2006

Language:

english

File:

PDF, 366 KB

english, 2006

38

Stereospecific Synthesis of syn -α-Oximinoamides by a Three-Component Reaction of Isocyanides, syn -Chlorooximes, and Carboxylic Acids

Pirali, Tracey, Mossetti, Riccardo, Galli, Simona, Tron, Gian Cesare

Journal:

Organic Letters

Year:

2011

Language:

english

File:

PDF, 848 KB

english, 2011

39

Efficient Synthesis of α-Ketoamides via 2-Acyl-5-aminooxazoles by Reacting Acyl Chlorides and α-Isocyanoacetamides

Mossetti, Riccardo, Pirali, Tracey, Tron, Gian Cesare, Zhu, Jieping

Journal:

Organic Letters

Year:

2010

Language:

english

File:

PDF, 322 KB

english, 2010

40

Synthesis, Biological Evaluation, and Molecular Docking of Ugi Products Containing a Zinc-Chelating Moiety as Novel Inhibitors of Histone Deacetylases

Grolla, Ambra A., Podestà, Valeria, Chini, Maria Giovanna, Di Micco, Simone, Vallario, Antonella, Genazzani, Armando A., Canonico, Pier Luigi, Bifulco, Giuseppe, Tron, Gian Cesare, Sorba, Giovanni

Journal:

Journal of Medicinal Chemistry

Year:

2009

Language:

english

File:

PDF, 916 KB

english, 2009

41

The NAMPT inhibitor FK866 reverts the damage in spinal cord injury

Emanuela Esposito, Daniela Impellizzeri, Emanuela Mazzon, Gohar Fakhfouri, Reza Rahimian, Cristina Travelli, Gian Cesare Tron, Armando A Genazzani, Salvatore Cuzzocrea

Journal:

Journal of Neuroinflammation

Year:

2012

Language:

english

File:

PDF, 220 KB

english, 2012

42

One-Pot Synthesis of Macrocycles by a Tandem Three-Component Reaction and Intramolecular [3+2] Cycloaddition

Tron, Gian Cesare, Zhu, Jieping, Pirali, Tracey

Journal:

Organic Letters

Year:

2006

Language:

english

File:

PDF, 70 KB

english, 2006

43

An Efficient Synthesis of Symmetric and Unsymmetric Bis-(β-aminoamides) via Ugi Multicomponent Reaction

La Spisa, Fabio, Feo, Alberto, Mossetti, Riccardo, Tron, Gian Cesare

Journal:

Organic Letters

Year:

2012

Language:

english

File:

PDF, 271 KB

english, 2012

44

Chemoselective Esterification of Phenolic Acids and Alcohols

Appendino, Giovanni, Minassi, Alberto, Daddario, Nives, Bianchi, Federica, Tron, Gian Cesare

Journal:

Organic Letters

Year:

2002

Language:

english

File:

PDF, 65 KB

english, 2002

45

Groebke multicomponent reaction and subsequent nucleophilic aromatic substitution for a convenient synthesis of 3,8-diaminoimidazo[1,2-a]pyrazines as potential kinase inhibitors

Guasconi, Margherita, Lu, Xiaoyun, Massarotti, Alberto, Caldarelli, Antonio, Ciraolo, Elisa, Tron, Gian Cesare, Hirsch, Emilio, Sorba, Giovanni, Pirali, Tracey

Journal:

Organic & Biomolecular Chemistry

Year:

2011

Language:

english

File:

PDF, 451 KB

english, 2011

46

Isocyanide Chemistry. Applications in Synthesis and Material Science. Herausgegeben von Valentine G. Nenajdenko.

Tron, Gian Cesare

Journal:

Angewandte Chemie

Year:

2012

Language:

german

File:

PDF, 274 KB

german, 2012

47

Isocyanide Chemistry. Applications in Synthesis and Material Science. Edited by Valentine G. Nenajdenko.

Tron, Gian Cesare

Journal:

Angewandte Chemie International Edition

Year:

2012

Language:

english

File:

PDF, 277 KB

english, 2012

48

Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2

Galli, Ubaldina, Mesenzani, Ornella, Coppo, Camilla, Sorba, Giovanni, Canonico, Pier Luigi, Tron, Gian Cesare, Genazzani, Armando A.

Journal:

European Journal of Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 488 KB

english, 2012

49

Regioselective Suzuki Coupling of Dihaloheteroaromatic Compounds as a Rapid Strategy To Synthesize Potent Rigid Combretastatin Analogues

Theeramunkong, Sewan, Caldarelli, Antonio, Massarotti, Alberto, Aprile, Silvio, Caprioglio, Diego, Zaninetti, Roberta, Teruggi, Alessia, Pirali, Tracey, Grosa, Giorgio, Tron, Gian Cesare, Genazzani, A

Journal:

Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 2.53 MB

english, 2011

50

Off the Beaten Track: The Use of Secondary Amines in the Ugi Reaction

Tron, Gian Cesare

Journal:

European Journal of Organic Chemistry

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013